BIOL: Molecular Cell & Dev Biology

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Course #
Course Title
Course Level
Units
BIOL 15
Undergraduate Research Reports
Lower Division
1 units
Undergraduate students who work in faculty research laboratories present the results of their projects. Organized by the Minority Undergraduate Research Program and the Minority Access to Research Careers Program. Designed for students with membership in the above-mentioned programs. Prerequisite(s): qualifications as determined by instructor at first class meeting. May be repeated for credit.
BIOL 20A
Cell and Molecular Biology
Lower Division
5 units
Introduction to biochemistry, cell biology, molecular biology, and genetics. Prerequisite(s): Chemistry 1A; students with a chemistry AP score of 4 or higher who wish to start their biology coursework prior to completing the Chemistry 1A, may enroll by permission of the instructor.
BIOL 20L
Experimental Biology Laboratory
Lower Division
2 units
Provides biology majors with the theory and practice of experimental biology. A wide range of concepts and techniques used in the modern laboratory are included in the exercises. Designed to satisfy the introductory biology lab requirement of many medical and professional schools. Students are billed a materials fee. Prerequisite(s): BIOL 20A and previous or concurrent enrollment in BIOE 20B. Enrollment restricted to human biology and health sciences majors; other majors by permission. Enrollment limited to 20.
BIOL 80A
Female Physiology and Gynecology
Lower Division
5 units
Biochemical, medical, social, and clinical aspects of the female body. Emphasis will be on biological-chemical interactions in the female organs. Topics include female anatomy, cell physiology, endocrine functions, sexuality and intimacy, sexually transmitted diseases, puberty, pregnancy, menopause, birth control, abortion, immunity, cancer. (General Education Code(s): SI.)
BIOL 80E
Evolution
Lower Division
5 units
Introduction to Darwinian evolution including how the theory was devised and a discussion of other theories proposed at the time. Explores the facts and evidence of evolutionary processes and the insights they provide in biological diversity, consequences of extinction, and emergence of new diseases. Includes a discussion of evolution and spirituality. (General Education Code(s): SI.)
BIOL 86
Research Deconstruction: MCD Biology
Lower Division
3 units
Explores scientific principles and logic through research seminars in molecular, cellular, and developmental biology. Additional topics may include diseases, stem cell biology, and other medically relevant areas in biomedical research. Prerequisite(s): Mathematics 3 or equivalent (i.e., mathematics placement examination score), and satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to first-year, sophomore, and junior students. Enrollment by permission of the instructor. Enrollment limited to 30.
BIOL 88
Studies in Medicine: Its Art, History, Science, and Philosophy
Lower Division
5 units
An interdisciplinary, multicultural, and historical perspective of medicine focused primarily upon therapy and practice to achieve better understanding of the scope, practice, and limits or medicine. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements. Enrollment by permission of instructor. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements. Enrollment limited to 30. (General Education Code(s): SI.)
BIOL 100
Biochemistry
Upper Division
5 units
An introduction to biochemistry including biochemical molecules, protein structure and function, membranes, bioenergetics, and regulation of biosynthesis. Provides students with basic essentials of modern biochemistry and the background needed for upper-division biology courses. Students who plan to do advanced work in biochemistry and molecular biology should take the Biochemistry and Molecular Biology 100 series directly. Students cannot receive credit for this course after they have completed any two courses from the BIOC 100A, 100B, and 100C sequence. Prerequisite(s): BIOL 20A and BIOE 20B; and CHEM 108A or 112A.
BIOL 100L
Biochemistry Laboratory
Upper Division
5 units
Basic techniques and principles of laboratory biochemistry including isolation and characterization of a natural product, manipulation of proteins and nucleic acids to demonstrate basic physical and chemical properties; and characterization of enzyme substrate interactions. Students are billed a materials fee. Enrollment restricted to biological sciences and affiliated majors; biology minors; non-majors by instructor permission. (Formerly Advanced Biochemistry Laboratory.) Prerequisite(s): BIOL 100 or BIOC 100A, and BIOL 100K or BIOL 20L or BIOL 101L; satisfaction of the Entry Level Writing and Composition requirements. Enrollment limited to 20.
BIOL 101
Molecular Biology
Upper Division
3 units
Covers the basic molecular mechanism of DNA replication and transcription, protein synthesis, and gene regulation in bacterial and eukaryotic organisms. The experimental techniques used to determine these mechanisms are emphasized. Unless students have already passed course 20L, they are strongly encouraged to enroll in course 101L. Prerequisite(s): course 100 or Biochemistry and molecular biology 100A.
BIOL 101L
Molecular Biology Laboratory
Upper Division
2 units
Laboratory course providing hands-on experience with, and covering conceptual background in, fundamental techniques in molecular biology and biochemistry, including DNA cloning, PCR, restriction digest, gel electrophoresis, protein isolation, protein quantification, protein immunoblot (Western) analysis, and use of online bioinformatics tools. Students are billed a materials fee. (Formerly Biochemistry Laboratory.) Previous or concurrent enrollment in BIOL 100, 101, or BIOC 100A is required. Students cannot receive credit for this course and BIOL 20L.
BIOL 102L
Toxic RNA Laboratory I
Upper Division
3 units
Introduces hypothesis-driven laboratory research. Students create models of a unique uncharacterized disease causing mutation and determine how it impacts the process of pre-mRNA splicing. An understanding of introductory molecular biology and genetics is required. Students are billed a materials fee. Prerequisite(s): course 20A and satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to sophomore, junior, and senior biological sciences and affiliated majors. Enrollment is by application and permission of the instructor. Enrollment limited to 25. (General Education Code(s): PR-E.)
BIOL 105
Genetics
Upper Division
5 units
Mendelian and molecular genetics; mechanisms of heredity, mutation, recombination, and gene action. Prerequisite(s): BIOL 20A and BIOE 20B.
BIOL 105L
Eukaryotic Genetics Laboratory
Upper Division
5 units
Classical and newly developed molecular-genetic techniques used to explore genetic variation in wild populations of the fruit fly Drosophila melanogaster. Topics include Mendelian fundamentals, mapping, design of genetic screens, bio-informatic and database analysis, genetic enhancers, and population genetics. Students are billed a materials fee. Enrollment restricted to biological sciences and affiliated majors; biology minors; non-majors by instructor permission. Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 100K or BIOL 20L or BIOL 101L; BIOL 105; satisfaction of Entry Level Writing and Composition Requirements.
BIOL 109L
Yeast Molecular Genetics Laboratory
Upper Division
5 units
Using budding yeast as an experimental organism, this laboratory provides practical experience in classic and modern molecular biology and in genetic and epigenetic methods, and develops strong scientific communication skills. Topics include mendelian genetics, linkage, gene replacement, chromatin immunoprecipitation and epigenetics. Students are billed a materials fee. Enrollment restricted to biological sciences and affiliated majors; biology minors. Non-majors enroll by instructor permission. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K or BIOL 20L or BIOL 101L, and BIOL 105. Satisfaction of the Entry Level Writing and Composition requirements. Enrollment limited to 20.
BIOL 110
Cell Biology
Upper Division
5 units
Covers the structure, organization, and function of eukaryotic cells. Topics include biological membranes, organelles, protein and vesicular trafficking, cellular interactions, the cytoskeleton, and signal transduction. Requires a good understanding of basic biochemistry and molecular biology. Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or 100K or 20L.
BIOL 110L
Cell Biology Laboratory
Upper Division
5 units
Fundamental aspects of cell biology explored through experimentation in a modern laboratory setting. Research topics include the structure and function of biological membranes; intracellular transport and organelle biogenesis; the cell cycle; and the cytoskeleton. Students are billed a materials fee. Enrollment restricted to biological sciences and affiliated majors; biology minors. Non-majors enroll by instructor permission. Prerequisite(s): BIOL 100 or BIOC 100A, and BIOL 100K or BIOL 20L or BIOL 101L, and previous or concurrent enrollment in BIOL 110. Satisfaction of the Entry Level Writing and Composition requirements. Enrollment limited to 16.
BIOL 111
Immunology
Upper Division
5 units
Immune systems--their manifestations and mechanisms of action. Prerequisite(s): BIOL 20A, BIOE 20B, BIOL 105, and BIOL 110.
BIOL 111A
Immunology I
Upper Division
5 units
Principles and concepts of the innate and adaptive immune systems, with emphasis on mechanisms of action and molecular and cellular networks. The development, differentiation, and maturation of cells of the immune system are also discussed. Prerequisite(s): courses BIOE 20B, and BIOL 20A, 105, and 110.
BIOL 111B
Immunology II
Upper Division
5 units
The immune system in health and disease, including failures of host immune-defense mechanisms, allergy and hypersensitivity, autoimmunity, transplantation biology, the immune response to tumors, immune-system interactions with pathogens, and manipulation of the immune response. Prerequisite(s): course 111A.
BIOL 112
Virology
Upper Division
3 units
Principles of virology illustrated through study of specific examples. Topics include: viral genome organization, viral assembly, virus-host interactions, genetic diversity of viruses, viral ecology, and the epidemiology of viral diseases. Prerequisite(s): courses 101 and 110 and consent of instructor. Enrollment limited to 25.
BIOL 114
Cancer Cell Biology
Upper Division
5 units
Focuses on the molecular and cellular mechanisms behind cancer. Topics covered include oncogenes, tumor suppressor genes, cell growth genes, checkpoint genes, telomeres, and apoptosis. Students will gain experience in reading the primary scientific literature. Prerequisite(s): BIOL 110 or 115. (General Education Code(s): TA.)
BIOL 115
Eukaryotic Molecular Biology
Upper Division
5 units
Covers eukaryotic gene and genome organization; DNA, RNA, and protein synthesis; regulation of gene expression; chromosome structure and organization; and the application of recombinant DNA technology to the study of these topics. Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or 100K. Enrollment restricted to biological sciences and affiliated majors, non-majors by permission of instructor.
BIOL 115L
Eukaryotic Molecular Biology Laboratory
Upper Division
5 units
A laboratory designed to provide students with direct training in basic molecular techniques. Each laboratory is a separate module which together builds to allow cloning, isolation, and identification of a nucleic acid sequence from scratch. Students cannot receive credit for this course and course 187L or 287L. Students are billed a materials fee. Restricted to biological sciences/affiliated majors; biology minors; other majors by permission. Prerequisite(s): BIOL 100 or BIOC 100A or CHEM 103, and BIOL 100K or BIOL 20L or BIOL 101L, and previous or concurrent enrollment in BIOL 101 or 115. Satisfaction of the Entry Level Writing and Composition requirements. Enrollment limited to 20.
BIOL 116
Advanced Topics in Cell Biology
Upper Division
3 units
Advanced course in cell biology featuring small-classroom discussion of topics related to the structure and function of cells and their organelles. Emphasis is given to experimental strategies used in cell biology research. Requires discussion of scientific literature and student-led presentations. Prerequisite(s): course 110. Enrollment restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor. Enrollment limited to 30.
BIOL 117
Global Health and Neglected Diseases
Upper Division
3 units
Neglected tropical diseases afflict more than 1 billion of the poorest individuals on the planet. This course covers the molecular basis and pathology of the most prevalent neglected diseases and emerging strategies to combat these diseases. (Formerly Neglected Tropical Diseases.) Prerequisite(s): course 110. Enrollment restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor. Enrollment limited to 30.
BIOL 118
Pathogenesis: Molecular Mechanisms of Disease
Upper Division
5 units
Overview of the pathogenic mechanisms underlying human disease at the physiological and molecular levels, with their implications for epidemiology, diagnosis, and treatment. Includes discussion of clinical cases and of emerging areas of research. Geared toward students interested in future research or clinical careers in the area of human or animal health. Students cannot receive credit for this course and Microbiology and Environmental Toxicology 238. (Also offered as Microbiol & Environ Toxicology 138. Students cannot receive credit for both courses.) Prerequisite(s): Biology 130. Enrollment restricted to students majoring in biology; human biology; molecular, cell and developmental biology; biochemistry and molecular biology; or neuroscience. Offered in alternate academic years.
BIOL 120
Developmental Biology
Upper Division
5 units
A description and analysis of selected developmental events in the life cycle of animals. Experimental approaches to understanding mechanisms are emphasized. (Formerly Development.) Prerequisite(s): course 110.
BIOL 120L
Development Laboratory
Upper Division
5 units
Experimental studies of animal development using a variety of locally obtainable organisms. Approximately eight hours weekly, but it will often be necessary to monitor continuing experiments throughout the week. Students are billed a materials fee. Enrollment restricted to biological sciences and affiliated majors; biology minors; other majors by permission. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K or BIOL 20L or BIOL 101L; satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in BIOL 120 is required.
BIOL 121L
Environmental Phage Biology Laboratory
Upper Division
5 units
Introduction to hypothesis-driven laboratory research. Students isolate a unique bacteriophage and characterize its structure and genome. An understanding of molecular biology and basic genetics required. Students are billed a materials fee. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K; satisfaction of the Entry Level Writing and Composition requirements. Enrollment restricted to biological sciences and affiliated majors with sophomore standing or higher. Enrollment by application and permission of instructor. Enrollment limited to 20.
BIOL 125
Introduction to Neuroscience
Upper Division
5 units
The structure and function of the nervous system. Topics include elementary electrical principles, biophysics and physiology of single nerve and muscle cells, signal transduction at synapses, development of the nervous system, and neural basis of behavior. Requires a good understanding of basic biochemistry, cell biology, and molecular biology. Prerequisite(s): BIOL 20A, BIOE 20B; and BIOL 101 or BIOC 100A; previous or concurrent enrollment in BIOL 110 is required.
BIOL 126
Advanced Molecular Neuroscience
Upper Division
5 units
Explores in detail cellular and molecular events that underlay the function of the nervous system. Topics include neural development, axon guidance and regeneration, advanced electrical principles (synaptic transmission through a variety of receptors), synaptic plasticity, learning and memory, as well as several neural disorders. Students cannot receive credit for this course and course 226. Prerequisite(s): Course 125. Enrollment restricted to neuroscience majors and proposed majors. (General Education Code(s): TA.)
BIOL 127
Mechanisms of Neurodegenerative Disease
Upper Division
5 units
Focuses on cellular and molecular processes that underlie neurodegenerative diseases. Includes lectures, student oral presentations, discussions, a term paper, and exams. Prerequisite(s):course 110. (General Education Code(s): TA.)
BIOL 128
Developmental Neurobiology
Upper Division
5 units
Covers the principles of nervous-system development from the molecular control of development, cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 228. Prerequisite(s): courses 110 and 125. Enrollment is restricted to juniors and seniors.
BIOL 130
Human Physiology
Upper Division
5 units
Function, organization, and regulation of the major organ systems of humans, with emphasis on integration among systems. Students cannot receive credit for this course and course 131. Prerequisite(s): BIOL 110.
BIOL 130L
Human Physiology Laboratory
Upper Division
2 units
Examines fundamental principles of systemic physiology focusing on the human. Students cannot receive credit for this course and BIOE 131L. Students are billed a materials fee. Enrollment is restricted to biological sciences and affiliated majors; biology minors; other majors by permission. Prerequisite(s): Satisfaction of Entry Level Writing and Composition requirements; BIOL 110; previous or concurrent enrollment in BIOL130 is required.
BIOL 178L
Protocols in Stem Cell Biology
Upper Division
5 units
Provides hands-on experience in embryonic stem cell culture methods and techniques. Students grow and passage mouse embryonic stem (mES) cells and perform established protocols that differentiate mES cells into cardiac muscle cells and neurons. Enrollment restricted to biological sciences and affiliated majors; biology minors; non-majors by permission. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K; satisfaction of the Entry Level Writing and Composition requirements; previous or concurrent enrollment in course 178. Enrollment limited to 16.
BIOL 186F
Undergraduate Research in MCD Biology
Upper Division
2 units
Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, is also discussed. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K or BIOL 20L or BIOL 101L. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment restricted to biology and affiliated majors. May be repeated for credit.
BIOL 186L
Undergraduate Research in MCD Biology
Upper Division
5 units
Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are also discussed. Prerequisite(s): Entry Level Writing and Composition requirements; BIOL 100 or BIOC 100A; and BIOL 100K or BIOL 20L or BIOL 101L. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment restricted to biology and affiliated majors.
BIOL 186R
Undergraduate Research in MCD Biology
Upper Division
5 units
Supervised undergraduate research in the laboratory of an MCD biology faculty member accompanied by weekly lectures on practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; ethics and scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are discussed. Students cannot receive credit for this course and course 186L. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 100K or BIOL 20L or BIOL 101L; previous completion of the Disciplinary Communication requirement. Each enrolled student must have a committed MCD faculty sponsor by the first class. Enrollment restricted to majors. May be repeated for credit.
BIOL 188
A Life in Medicine
Upper Division
3 units
Students explore healthcare from the perspectives of both clinicians and patients. The class focuses on medicine's cognitive, emotional, and spiritual elements, with the goal of understanding the rewards and costs of healthcare practice. (Formerly Life in Healthcare.) Enrollment restricted to junior and senior human biology majors, and others by permission of instructor. Enrollment limited to 30. (General Education Code(s): PR-E.)
BIOL 189
Health Sciences Internship
Upper Division
3 units
Structured off-campus learning experience providing experience and pre-professional mentoring in a variety of health-related settings. Interns are trained and supervised by a professional at their placement and receive academic guidance from their faculty sponsor. Students spend 8 hours per week at their placement, participate in required class meetings on campus, and keep a reflective journal. Enrollment by application. Students interview with health sciences internship coordinator; applications are due one quarter in advance to the Health Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements; concurrent enrollment in course 189W is required. Enrollment restricted to human biology majors.
BIOL 189W
Disciplinary Communication: Human Biology
Upper Division
2 units
Writing-intensive course offered in conjunction with the health sciences internship. Weekly class meetings include academic guidance and mentoring as well as discussion of the mechanisms and conventions of academic writing about heath and health care. Students complete multiple writing assignments, culminating in a term paper in the format of a scholarly article. Enrollment by application. Students interview with the health-sciences internship coordinator; applications are due one quarter in advance to the Health Care Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in course 189 is required. Enrollment restricted to human biology majors.
BIOL 191
ACE Program Service Learning
Upper Division
2 units
Students participate in training and development to co-facilitate collaborative learning in ACE chemistry discussion sections and midterm/exam review sessions. Students are role models for students pursuing science- and math-intensive majors. Prerequisite(s): Prior participation in ACE; good academic standing; no non-passing grades in prior quarter. Enrollment restricted to sophomores, juniors, and seniors. (Formerly course 182.) Enrollment limited to 10. (General Education Code(s): PR-S.)
BIOL 198
Independent Field Study
Upper Division
5 units
Provides for individual programs of study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. With permission of the department, may be repeated for credit, or two or three courses taken concurrently. Students submit petition to sponsoring agency. May be repeated for credit.
BIOL 198F
Independent Field Study
Upper Division
2 units
Provides for two credits of independent field study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. Students submit petition to sponsoring agency. May be repeated for credit.
BIOL 199
Tutorial
Upper Division
5 units
Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency. May be repeated for credit.
BIOL 199F
Tutorial
Upper Division
2 units
Two-credit Tutorial. Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency. May be repeated for credit.
BIOL 200A
Critical Analysis of Scientific Literature
Graduate
5 units
Development of critical thinking skills via discussion of research articles on a broad range of topics. Prepares students to critically evaluate research publications, and improves their ability to organize effective oral presentations and to evaluate the oral presentations of other scientists. Enrollment restricted to graduate students in MCD biology, or by permission of instructor. Enrollment limited to 20.
BIOL 200B
Advanced Molecular Biology
Graduate
5 units
An in-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins. Discussion of the roles of macromolecules in the regulation of information in the cell. Prerequisite(s): Enrollment restricted to graduate students.
BIOL 200C
Advanced Cell Biology
Graduate
5 units
An in-depth coverage of topics in cellular and subcellular organization, structure, and function in plants and animals. Emphasis on current research problems. Prerequisite(s): BIOL 200B. Enrollment restricted to graduate students.
BIOL 200D
Developmental Biology
Graduate
5 units
Key topics in developmental biology, including developmental genetics, epigenetics, stem cell biology, and developmental neurobiology. Lectures are accompanied by critical analysis and discussion of recent publications. Enrollment restricted to graduate students in MCD biology, or by permission of instructor. Enrollment limited to 20.
BIOL 201
RNA Processing
Graduate
5 units
An advanced graduate-level course on biological aspects of RNA function and processing in eukaryotes. Lectures and discussions will be developed using the current literature. Prerequisite(s): BIOL 200B or permission of instructor. Enrollment restricted to graduate students. Enrollment limited to 15.
BIOL 203
Ribosomes and Translation
Graduate
5 units
Covers the field of ribosome research in depth, including the structure and function of ribosomes and the molecular mechanisms of protein synthesis. Begins with historical review of the ribosome field and proceeds to the most recent findings. Focus is on central questions: (1) How is the accuracy of the aminoacyl-tRNA selection determined? (2) What is "accommodation"? (3) What is the mechanism of peptide bond formation (peptidyl transferase)? (4) What is the mechanism of translocation? (5) What are the mechanistic roles of the ribosome and translation factor EF-G in translocation? (6) To what extent is the mechanism of translation determined by RNA? (7) Why is RNA so well suited for the ribosome? (8) How did translation evolve from an RNA world? Prerequisite(s): BIOC 100A,BIOL 200B or permission of instructor. Enrollment restricted to graduate students.
BIOL 204
Chromatin
Graduate
5 units
Eukaryotic DNA is complexed with histones to form chromatin. This course focuses on the ways in which chromatin influences and is manipulated to regulate gene expression. Prerequisite(s): BIOL 105 and BIOL 115; undergrads by permission of instructor. Enrollment restricted to graduate students. Enrollment limited to 15. Offered in alternate academic years.
BIOL 205
Epigenetics
Graduate
5 units
In-depth coverage of epigenetics focusing on how alterations in chromatin structure and DNA methylation establish and maintain heritable states of gene expression. Lectures are supplemented with critical discussion of recent publications. Prerequisite(s): BIOL 105 and BIOL 115, or permission of instructor. Enrollment restricted to graduate students. Enrollment limited to 20.
BIOL 206
Introduction to Stem Cell Biology
Graduate
5 units
Fundamental concepts, experimental approaches, and current advances in stem cell biology, with consideration of key ethical issues. Topics include: self-renewal and differentiation; the microenvironment; epigenetics; cell-cycle regulation; and how basic research translates to medical therapeutics. Ethical, moral, and political issues surrounding stem cell research are discussed with lectures from philosophy and other relevant disciplines. Enrollment restricted to graduate students. Enrollment limited to 15.
BIOL 206L
Current Protocols in Stem Cell Biology
Graduate
5 units
Provides students with hands-on experience in embryonic stem cell culture methods. Enrollment restricted to graduate students; qualified undergraduates may enroll by permission of instructor. Enrollment limited to 10.
BIOL 208
Cellular Signaling Mechanisms
Graduate
5 units
All eukaryotic cells utilize intricate signaling pathways to control such diverse events as cell-cell communication, cell division, and changes in cell morphology. This course covers the molecular basis of these cellular signaling pathways, focusing on the most current research. Prerequisite(s): BIOL 105, BIOL 110, and BIOL 115. Enrollment restricted to seniors and graduate students. Enrollment limited to 15. Offered in alternate academic years.
BIOL 214
Advances in Cancer Biology
Graduate
5 units
Provides students with knowledge of the latest concepts in cancer biology and cancer therapeutics, and a general appreciation of the rapid advances being made in this area of biomedicine. Prerequisite(s): course 200B or by permission of instructor. Enrollment restricted to graduate students. Enrollment limited to 15.
BIOL 215
Applied Statistics for Molecular, Cell, and Developmental Biology
Graduate
5 units
For experimental biologists: focuses on resolving practical statistical issues typically encountered in molecular, cellular, and developmental biology lab research. No prior experience in statistics or programming is necessary. Enrollment restricted to graduate students in molecular, cellular, and developmental biology. Enrollment limited to 20.
BIOL 217
Influence of Environment and Experience on Brain Development
Graduate
5 units
How environmental factors (animals' experiences, environmental toxins, etc.) affect the formation of neuronal circuits and brain function. Lectures and discussions use current literature. Prerequisite(s): courses 200A, 200B, 200C, and 200D, or by permission of the instructor. Enrollment is restricted to graduate students. Enrollment limited to 10.
BIOL 226
Advanced Molecular Neuroscience
Graduate
5 units
Basis of neural behavior at the cellular, molecular and system levels. First half of course focuses on cellular, molecular, and developmental aspects of the nervous system and covers two sensory systems: olfaction and auditory. Last half of course concerns higher-level functions of the nervous system, such as processing and integrating information. Discusses human diseases and disorders. Enrollment restricted to graduate students.
BIOL 228
Developmental Neurobiology
Graduate
5 units
Covers the principles of nervous-system development from the molecular control of development, and cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 128. Enrollment is restricted to graduate students and by permission of the instructor.
BIOL 280A
Topics in Research on Molecular Genetics of Yeast
Graduate
2 units
Intensive research seminar on the structure and function of the gene expression machinery in the simple eukaryote Saccharomyces cervisiae and its relationship to the human gene expression machinery. Enrollment restricted to graduate students; qualified undergraduates may enroll with approval of instructor. May be repeated for credit.
BIOL 280B
Chromatin Structure and Transcriptional Regulation
Graduate
2 units
Weekly seminar on structure and gene regulatory function of chromatin. Discusses research of participants and relevant scientific literature. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280C
Mammalian Brain Development
Graduate
2 units
Seminar covers research into the development of the mammalian brain. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280D
RNA Processing
Graduate
2 units
A discussion of current research and literature concerning the regulation of precursor messenger RNA processing. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280E
Meiotic Chromosome Dynamics
Graduate
2 units
Intensive course on the molecular mechanisms underlying homolog pairing, synapses, and recombination; and how they are regulated, coordinated, and monitored to ensure accurate meiotic chromosome segregation. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. May be repeated for credit.
BIOL 280F
Development of Vertebrate Neural Connections
Graduate
2 units
Intensive research seminar on molecular mechanisms by which neural connections are established during mouse development. Special focus on topographic maps and role of Eph receptors and ephrins in this process. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. May be repeated for credit.
BIOL 280G
Physiology of the Developing Brain
Graduate
2 units
Research seminar covering circuit structure and function in the developing brain. Enrollment is restricted to graduate students; undergraduates may enroll by permission of the instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280H
Topics on Research into Chromatin and Transcription
Graduate
2 units
Seminar covering research into the effects of chromatin on transcription in yeast. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280I
Epigenetic Gene Silencing and Insulators
Graduate
2 units
Intensive course on molecular mechanisms by which insulator elements regulate epigenetic gene silencing. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. May be repeated for credit.
BIOL 280J
Structures of Macromolecular Complexes
Graduate
2 units
Focuses on structure and function of the spliceosome using electron microscopy and x-ray crystallography. Participants present results from their own research and relevant journal articles. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 20. May be repeated for credit.
BIOL 280K
Topics in Cell Cycle Research
Graduate
2 units
An intensive seminar focusing on current research on the molecular mechanisms that control cell division. Participants are required to present results of their own research or to review journal articles of interest. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor.
BIOL 280L
Development
Graduate
2 units
Seminar covering research into breast development and cancer. (Formerly Topics on Neural Development.) Enrollment restricted to graduate students. Enrollment limited to 12. May be repeated for credit.
BIOL 280M
Post-Transcriptional Control of Mammalian Gene Expression
Graduate
2 units
Intensive course on the molecular mechanisms by which RNA binding proteins regulate gene expression. Enrollment restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor. Enrollment limited to 8. May be repeated for credit.
BIOL 280N
Long Noncoding RNA and the Immune System
Graduate
2 units
Weekly seminar discussion of the current research and literature concerning the functions for long noncoding RNA in gene regulation within inflammatory signaling pathways. Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280O
Topics in Bacterial Pathogenesis
Graduate
2 units
Intensive seminar focusing on mechanisms of bacterial pathogenesis of the ulcer-causing bacterium Helicobacter pylori. Participants are required to present results from their own research and relevant journal articles. (Also offered as Microbiol & Environ Toxicology 281O. Students cannot receive credit for both courses.) Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 20. May be repeated for credit.
BIOL 280Q
Cell Biology of Oocytes, Embryos, and Neurons
Graduate
2 units
Weekly seminar and round-table discussion about research problems and recent advances in molecular motor proteins, cytoskeletons, and the control of force-producing processes. Each participant reports recent advances in their field from current literature, their own primary research questions, current approaches to answering those questions, and their research progress. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280R
Gene regulation in C. elegans and human parasitic namtodes
Graduate
2 units
Intense weekly seminar on the mechanisms of gene regulation, focusing on C. elegans and human parasitic nematodes. Enrollment is restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280S
Chromatin and RNA Regulation in C. elegans
Graduate
2 units
Intensive research seminar about regulators of chromatin organization; the composition and function of germ granules; and the roles of both levels of regulation in germline development in C. elegans. Participants present their research results and report on related journal articles. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280T
Molecular Biology of Drosophila Development
Graduate
2 units
An intensive seminar concerning the molecular genetics of Drosophila. Recent research is discussed weekly, with an emphasis on gene regulation and development. Students present their own research or critical reviews of recent articles at least once during the quarter. Enrollment restricted to graduate students. Qualified undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280U
Discussions on the Development of the Drosophila Embryo
Graduate
2 units
Involves a two-hour weekly meeting in which the students discuss topics concerning the cell cycle, early embryonic development, and the cytoskeleton. These discussions critically evaluate ongoing research in this area. Material is drawn from student research and recently published journal articles. Students are also expected to meet individually with the instructor two hours weekly. In addition to a three–five page research proposal, each student gives two one-hour oral presentations. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. May be repeated for credit.
BIOL 280W
Membrane Proteins
Graduate
2 units
Seminar on recent research on membrane proteins, with an emphasis on ion-pumping ATPase. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 20. May be repeated for credit.
BIOL 280Y
Activity-Dependent Synaptic Plasticity
Graduate
2 units
Research seminar covering the regulation of synaptic plasticity in the mammalian nervous system, focusing on how the activity regulates the structural and functional dynamics of synapses. Enrollment restricted to graduate students; undergraduates may enroll with permission of instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 280Z
Prostate Development and Cancer Biology
Graduate
2 units
Weekly research seminar covering gene regulation, cellular interactions, and stem cell behaviors in mammalian prostate development and prostate cancer progression. Enrollment is restricted to graduate students; undergraduates may enroll by the permission of the instructor. Enrollment limited to 10. May be repeated for credit.
BIOL 288
Teaching Assistant Training
Graduate
2 units
Prepares graduate students to help teach university science courses. Weekly class sessions include activities and interactive discussions of diverse modes of learning, diverse ways of teaching, peer instruction, assessment of learning, equity and inclusion, and professional ethics. Students also visit an active learning class and an active learning discussion section at UCSC, then write evaluations of the teaching strategies used in those classes. Enrollment is restricted to graduate students.
BIOL 289
Practice of Science
Graduate
5 units
Examination of ethical and practical scientific issues, including the collection and treatment of data, attribution of credit, plagiarism, fraud, and peer review. Career issues, including how to apply for grants and positions in industry or academia, will be discussed. Prerequisite(s): BIOL 200A, BIOL 200B, and BIOL 200C or permission of instructor. Enrollment restricted to graduate students; undergraduates may enroll with permission of the instructor. Enrollment limited to 20.
BIOL 290
Career Planning
Graduate
2 units
An important goal of graduate programs is to train students for diverse careers. Exposes molecular cell and developmental biology graduate students to diverse career options and helps them develop individual development plans to target their graduate training to their selected career goals. Enrollment is restricted to graduate students.
BIOL 291
Molecular, Cellular, and Developmental Biology Seminar
Graduate
2 units
Topics of current interest in molecular, cellular, and developmental biology are presented weekly by graduate students, faculty, and guest speakers. Enrollment restricted to graduate students. Enrollment limited to 60. May be repeated for credit.
BIOL 292
MCD Seminar
Graduate
0 units
Various topics by weekly guest speakers. Enrollment restricted to graduate students.