METX: Microbio & Enviro Toxicology

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Course #
Course Title
Course Level
Units
METX 80E
Aquatic Toxicology
Lower Division
5 units
An introduction to the sources, cycling, and impacts of toxicants in aquatic systems, including acid rain, ground water, fresh water rivers and lakes, estuaries, and the ocean. Emphasis is on the properties of toxic chemicals that influence their biogeochemical cycles and factors that influence their toxicity to aquatic organisms and humans. (General Education Code(s): SI.)
METX 101
Sources and Fates of Pollutants
Upper Division
5 units
Presents in-depth important principles of environmental toxicology related to the introduction, transport, and fate of toxicants in aquatic and terrestrial environments, including environmental chemistry and biogeochemical cycles as well as exposure pathways and uptake by organisms. Additional emphasis placed on susceptibility and effects of toxicants across organ systems, toxicokinetic and biomarkers of exposure, and effects at the ecosystem level. Students cannot receive credit for this course and course 201.
METX 102
Cell and Molecular Toxicology
Upper Division
5 units
Emphases of biochemical, cellular, and organ system basis of intoxication, including dose-response relationships, biotransformation of toxicants, biochemical mechanisms underlying toxicity, factors influencing toxic action, and biomarkers of exposure. Emphasizes effects of various classes of toxins, including heavy metals and persistent synthetic organics, with a focus on susceptible biochemical/cellular processes of the central nervous, immune, hepatic, and renal target organ systems. Designed for advanced undergraduates. Students cannot receive credit for this course and course 202. (Formerly Cellular and Organismal Toxicology.) Prerequisite(s): Biology 20A and 20B or equivalent; Biology 100, Biochemistry, and 110, Cell Biology, are recommended. Enrollment restricted to juniors and seniors.
METX 119
Microbiology
Upper Division
5 units
Cell and molecular biology of bacteria and their viruses, including applications in medicine, public health, agriculture, and biotechnology. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 101 and 101L.
METX 119L
Microbiology Laboratory
Upper Division
5 units
An introduction to the principles and practices of laboratory microbiology, with a substantial presentation of optical microscopy. Students are billed a materials fee. Prerequisite(s): previous or concurrent enrollment in course 119 required; satisfaction of Entry Level Writing and Composition requirements. Enrollment restricted to biological sciences and affiliated majors; biology minors; other majors by permission.
METX 125
Practicing Safe Science
Upper Division
2 units
Introduces research safety principles and practices. Instructors and guest experts discuss research hazards and control measures. Students explore the safe use of research methods and materials via hands-on and outside exercises. Issues include compliance with hazardous waste and other environmental safety regulations.
METX 135
Functional Anatomy
Upper Division
5 units
A rigorous systems-based course in anatomy. Lectures provide an overview of functional anatomy at all levels from the systems to the tissues. Provides a mechanistic understanding of the structures of the body as a foundation for human-health oriented studies. (Formerly BIOL 135.) Prerequisite(s): courses 20A and Biology: Ecology and Evolutionary 20B. Concurrent enrollment in course 135L is required. Enrollment restricted to biological sciences majors and affiliated majors and biology minors.
METX 135C
Cadaver Dissection Laboratory
Upper Division
2 units
Dissection of a human cadaver under the direction of an anatomy instructor. Prerequisite(s): course 135 and 135L, or Biology 135 and 135L, or Anthropology 102A. Enrollment limited to 16. May be repeated for credit.
METX 135L
Functional Anatomy Lab
Upper Division
2 units
Complements lecture course 135. Emphasizes nomenclature and recognition; includes the embryology and histology of bones, muscles, and internal organs, and the interactions between the systems of the body. Students are billed a materials fee. (Formerly BIOL 135L.) Prerequisite(s): BIOL 20A and BIOE 20B. Enrollment restricted to biological sciences majors and affiliated majors and biology minors. Concurrent enrollment in METX 135 is required. Enrollment limited to 24.
METX 138
Pathogenesis: Molecular Mechanisms of Disease
Upper Division
5 units
Overview of the pathogenic mechanisms underlying human disease at the physiological and molecular levels, with their implications for epidemiology, diagnosis, and treatment. Includes discussion of clinical cases and of emerging areas of research. Geared toward students interested in future research or clinical careers in the area of human or animal health. Students cannot receive credit for this course and Microbiology and Environmental Toxicology 238. (Also offered as Biology: Molecular Cell & Dev 118. Students cannot receive credit for both courses.) Prerequisite(s): Biology 130. Enrollment restricted to students majoring in biology; health sciences; molecular, cell, and developmental biology; biochemistry and molecular biology; or neuroscience and behavior. Offered in alternate academic years.
METX 140
Molecular Biology of Prokaryotes
Upper Division
5 units
Focuses on several aspects of prokaryotic molecular biology. Covers transcriptional regulation, translational regulation, DNA replication and segregation, protein secretion, transport of small molecules, control of metabolism, stress response, bacterial differentiation, signal transduction, biofilm formation, and motility. Strong focus on experimental techniques and approaches used in prokaryotic molecular biology. Focus on model bacteria such as Escherichia coli and Bacillus subtilis.Students cannot receive credit for this course and course 240. Prerequisite(s): Biology 119.
METX 144
Groundwater Contamination
Upper Division
5 units
Analyses of contemporary problems in groundwater contamination, based on current scientific understanding of contaminant transport in aquifers. Topics include both theoretical concepts and case studies. Prerequisite(s): Earth Science 110B. Offered in alternate academic years.
METX 145
Medical Geology
Upper Division
5 units
An interdisciplinary analysis of natural geochemical processes that impact human health and of anthropogenic processes that exacerbate those impacts. Prerequisite(s): Chemistry 1A, 1B, 1C, 1M, and 1N.
METX 150
Introduction to Research and Experimental Design
Upper Division
5 units
Lecture-based course for advanced undergraduates actively engaged in undergraduate research (e.g., independent study or senior thesis). Emphasizes basic lab skills, including laboratory safety and handling of laboratory equipment; experimental design; scientific record keeping; and literature searching, review, and management.
METX 151
Scientific Writing and Presentation
Upper Division
5 units
For advanced undergraduates who are actively engaged in undergraduate research (e.g., independent study or senior thesis). Emphasizes the collection, reduction, analysis, management, and interpretation of scientific data; the presentation of scientific data in written and oral formats; and further development of critical thinking. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements.
METX 160
Coastal Environmental Toxicology and Policy
Upper Division
3 units
Interdisciplinary analysis of the scientific basis and policy development to regulate and manage environmental pollutants in coastal waters. Focuses on case studies involving aspects of environmental toxicology and policy including environmental monitoring and regulatory programs; ecosystem restoration; and regulating the environmental impacts of coastal development. Enrollment restricted to sophomores, juniors, seniors, and graduate students.
METX 170
Drug Action and Development
Upper Division
5 units
Lectures and case studies explore principles and approaches in drug discovery and development, emphasizing concepts in pharmacology; medicinal chemistry; and genomics- and bioinformatics-based approaches to drug discovery to illustrate pathways from discovery through development for clinical use. Cannot receive credit for this course and course 270. (Formerly Frontiers in Drug Action and Discovery.) (Also offered as Chemistry and Biochemistry 170 and Biomolecular Engineering 170. Students cannot receive credit for both courses.) Prerequisite(s): Biology 100 or Chemistry 103 or Biochemistry 100A. Biology 110 and 130/L or 131/L are recommended. Enrollment restricted to juniors and seniors.
METX 200
Interdisciplinary Approaches in Environmental Toxicology
Graduate
5 units
Introduction to interdisciplinary, case-based approaches to problem-solving. Demonstrates how important, current problems in environmental and human health have been addressed and solved. Presents assigned problems that integrate the different organization levels (environmental, molecular/cellular, organismal/public health) inherent to environmental and human health. Students work in collaborative teams to analyze each problem and create a proposal for a research plan/solution. Enrollment restricted to graduate students. Advanced undergraduates may enroll by permission of the instructor.
METX 201
Sources and Fates of Pollutants
Graduate
5 units
Presents in-depth important principles of environmental toxicology related to the introduction, transport, and fate of toxicants in aquatic and terrestrial environments including environmental chemistry and biogeochemical cycles as well as exposure pathways and uptake by organisms. Additional emphasis will be placed on the susceptibility and effects of toxicants across organ systems, toxicokinetics and biomarkers of exposure, and effects at the ecosystem level. Students cannot receive credit for this course and course 101. Enrollment restricted to graduate students; qualified undergraduate science majors may enroll with permission of instructor.
METX 202
Cell and Molecular Toxicology
Graduate
5 units
Emphasizes biochemical, cellular, and organ system basis of intoxication, including dose-response relationships, biotransformation of toxicants, biochemical mechanisms underlying toxicity, factors influencing toxic action, and biomarkers of exposure. Emphasizes effects of various classes of toxins, including heavy metals and persistent synthetic organics, with a focus on susceptible biochemical/cellular processes of the central nervous, immune, hepatic, and renal target organ systems. Students cannot receive credit for this course and Microbiology and Environmental Toxicology 102 or BIOL 122.. (Formerly "Cellular and Organismal Toxicology.") Enrollment restricted to graduate students.
METX 203
Cellular and Molecular Toxicology
Graduate
5 units
Presents in-depth cellular and molecular principles of environmental toxicology. These include modes of action and cellular and molecular targets of toxicants, as well as mechanisms of cellular and molecular responses to toxicants and their detoxification. State-of-the-art biological methodologies and approaches to identify and study cellular targets of toxicants. Designed to provide students with a broad and deep understanding of the biological aspects of toxicology at both cellular and molecular levels, and the skills to approach emerging challenges in the field. Enrollment restricted to graduate students; qualified undergraduates may enroll with instructor's permission.
METX 205
Scientific Skills, Ethics, and Writing
Graduate
5 units
Provides fundamental training of graduate students in the scientific method; experimental design; ethics in science; grant proposal and scientific writing; and data presentation and scientific speaking. Students are evaluated on class participation, performance, and a written NIH/NSF-style research proposal. Advanced undergraduates may enroll with permission of the instructor. Enrollment restricted to graduate students.
METX 206A
Advanced Microbiology
Graduate
5 units
Focuses on aspects of bacterial molecular biology. Covers four main areas: (1) metabolism-catabolism, anabolism, building-block precursors; (2) transcription/signal transduction; (3) replication/plasmid biology/division; (4) translation/protein processing/secretion/cell structure. Strong focus on experimental techniques and approaches used in molecular biology, and on model bacteria, such as Escherichia coli and Bacillus subtilis. Enrollment restricted to graduate students. Advanced undergraduates may enroll with permission of instructor.
METX 210
Molecular and Cellular Basis of Bacterial Pathogenesis
Graduate
5 units
Focuses on the molecular basis of bacterial pathogenesis with specific emphasis on gene expression, regulation, and ecology and evolution. Enrollment restricted to graduate students. Advanced undergraduates with extensive background in microbiology and biology may enroll with permission of instructor.
METX 215
Antibiotics: Actions and Resistance
Graduate
3 units
Critical review of scientific literature covering genetic and physiological mechanisms conferring resistance to antibiotics and their spread in the population. Format based on structured discussion of selected topics and original research proposal. (Formerly Seminar in Advanced Prokaryotic Molecular Biology.) Prerequisite(s): course 206A or course 119, or by permission of the instructor. Enrollment is restricted to graduate students. Enrollment limited to 12.
METX 238
Pathogenesis: Molecular Mechanisms of Disease
Graduate
5 units
Provides an overview of the mammalian innate immune response and the role of inflammation in disease. Also, presents how both environmental stressors and microbial pathogens impact inflammation. Enrollment restricted to graduate students.
METX 240
Molecular Biology of Prokaryotes
Graduate
5 units
Focuses on several aspects of prokaryotic molecular biology. Covers transcriptional regulation, translational regulation, DNA replication and segregation, protein secretion, transport of small molecules, control of metabolism, stress response, bacterial differentiation, signal transduction, biofilm formation, and motility. Strong focus on experimental techniques and approaches used in prokaryotic molecular biology. Focus on model bacteria such as Escherichia coli and Bacillus subtilis.Students cannot receive credit for this course and course 140.
METX 250
Environmental Microbiology
Graduate
5 units
How microbes interact with their environments. Topics include anaerobic metabolism; biotransformation of toxic metals and organic pollutants; geomicrobiology; life in extreme environments; water quality. Advanced undergraduates with extensive background in microbiology and biology may enroll with permission of instructor. Enrollment restricted to graduate students. Offered in alternate academic years.
METX 270
Drug Action and Development
Graduate
5 units
Lectures and case studies explore principles and approaches in drug discovery and development, emphasizing concepts in pharmacology; medicinal chemistry; and genomics- and bioinformatics-based approaches to drug discovery to illustrate pathways from discovery through development for clinical use. Cannot receive credit for this course and course 170. (Formerly Frontiers in Drug Action and Discovery.) (Also offered as Chemistry and Biochemistry 270 and Biomolecular Engineering 270. Students cannot receive credit for both courses.) Enrollment restricted to graduate students.
METX 281A
Topics in Environmental Toxicology
Graduate
5 units
Selected topics in environmental toxicology. Topics vary from year to year. Enrollment restricted to graduate students; qualified upper-division science majors may enroll with instructor's permission. May be repeated for credit.
METX 281C
Topics in Environmental Microbiology
Graduate
2 units
Seminar and discussion focusing on mechanism of microbial transformation of metals. Participants present results from their research projects in a seminar format. Relevant journal articles presented and discussed. Enrollment restricted to graduate students; qualified undergraduates may enroll with instructor's permission.
METX 281F
Topics in Aquatic Toxicology
Graduate
2 units
Analyses of the sources and fates of aquatic pollutants. Discussions on processes at the air-water interface, within the water column, and in aquatic sediments. Topics vary from year to year. Enrollment restricted to graduate students; qualified upper-division science majors may enroll with instructor's permission. May be repeated for credit.
METX 281M
Topics in Molecular Toxicology
Graduate
2 units
Seminar and discussion on the mechanisms of toxicity in DNA alkylating agents. Participants present results from their research, and relevant journal articles are discussed. Enrollment restricted to graduate students. Undergraduates may enroll with instructor's permission. Enrollment limited to 5. May be repeated for credit.
METX 281O
Topics in Bacterial Pathogenesis
Graduate
2 units
Intensive seminar focusing on mechanisms of bacterial pathogenesis of the ulcer-causing bacterium Helicobacter pylori. Participants are required to present results from their own research and relevant journal articles. (Also offered as Biology: Molecular Cell & Dev 280O. Students cannot receive credit for both courses.) Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. Enrollment limited to 20. May be repeated for credit.
METX 281S
Cellular and Organismal Responses to Toxicants
Graduate
2 units
Intensive research seminar on the concepts, theory, and techniques in deriving physiologically based pharmacokinetic models of toxin exposure, metabolism, and efficacy of therapeutic treatment in mammalian models of human metal toxicity. Enrollment restricted to graduate students; qualified undergraduates may enroll with permission of instructor. May be repeated for credit.
METX 281V
Topics in Bacterial Pathogenesis and Innate Immunity
Graduate
2 units
Focuses on the interplay between the human gut bacterial pathogen Yersinia pseudotuberculosis and the innate immune system of the host. Participants are required to present the goals, results, and conclusions from their own research. Participation in the general discussion during others' presentations is also required. Enrollment restricted to graduate students. Qualified undergraduates performing research under the supervision of the instructor may enroll with instructor's permission. May be repeated for credit.
METX 281Y
Biofilms: Processes and Regulation
Graduate
2 units
Intensive seminar series focusing on the most current work on genes and the processes that regulate biofilm development dynamics as well as on the recent developments on visualization of biofilms. Presentation and discussion based. Enrollment restricted to graduate students. Qualified undergraduate students may enroll with instructor's permission. May be repeated for credit.
METX 282
Current Approaches to Molecular Pathogenesis
Graduate
2 units
Graduate level seminar focusing on the mechanisms by which bacterial pathogens cause disease. Specific topics include basic concepts of virulence and virulence factors, virulence factor regulation, toxins, and interactions of pathogens with mammalian cells and organs. Discussions focus on several key pathogens, including Helicobacter pylori, Vibrio cholerae, Salmonella typhimuruim, and Listeria monocytogenes. May be repeated for credit.
METX 290
Proseminar
Graduate
5 units
Special topics offered from time to time by faculty, visiting professors, or staff members. Enrollment restricted to graduate students; qualified undergraduates may enroll with instructor's permission. May be repeated for credit.
METX 290A
Epidemiology and Risk Assessment
Graduate
5 units
Approaches different techniques of biological monitoring and the exposure and effect of biomarkers related to occupational and environmental exposure to chemicals. Available methods for risk assessment and identification of protective exposure limits also considered. (Formerly Biological Impact of Chemical Exposures.)
METX 292
Introductory Graduate Seminar
Graduate
0 units
Weekly seminars by academic and research faculty on their areas of special interest. Students write weekly abstracts on articles covered by the seminars. Enrollment restricted to graduate students; qualified undergraduates may enroll with instructor's permission.